Comparison of Sperm Selection Techniques in ICSI: Microfluidics vs. Centrifugation Gradient
The study compares two sperm selection techniques in 239 couples undergoing IVF-ICSI: the traditional centrifugation gradient method and the microfluidic technique (ZyMot ICSI). Although there were no significant differences in fertilization rates (p = 0.87), the use of microfluidics improved the blastocyst rate (p = 0.046) and clinical pregnancy (p = 0.049). The results suggest […]
Use of Microfluidics to Reduce Sperm DNA Fragmentation and Improve ICSI Outcomes
The study evaluates the use of a microfluidic device (FertileChip®, now ZyMot® ICSI) to reduce double-strand sperm DNA fragmentation, a factor associated with recurrent miscarriages and low implantation rates. In a pilot study with nine patients, the device reduced fragmentation by 46% compared to the conventional «swim-up» method. Subsequently, in 163 ICSI cycles, fertilization rates […]
Impact of the Microfluidic Device in ICSI: Improving Outcomes in Patients with High Sperm DNA Fragmentation
The study evaluates the impact of the ZyMōt™ ICSI microfluidic device on ICSI outcomes in couples with high sperm DNA fragmentation (DSB). Comparing two ICSI cycles in 28 couples—the first using conventional methods and the second using ZyMōt™ ICSI—significant improvements in clinical outcomes were observed. The biochemical pregnancy rate increased by 28.31%, the clinical pregnancy […]
New Oral Supplementation to Reduce Sperm DNA Damage and Improve Male Fertility
The study investigates a new oral supplementation based on the Ataxia-Telangiectasia-Mutated (ATM) gene repair pathway to reduce sperm DNA damage and improve semen parameters in infertile men. Three formulations were tested, including two containing curcumin and Ginkgo Biloba extract, measuring DNA damage levels and semen quality in 71 patients after 13 weeks. The formulation with […]
ASRM-Validation of LensHooke® X1 PRO and Computer-Assisted Semen Analyzer Compared with Laboratory-Based Manual Semen Analysis
Introduction Infertility is prevalent in approximately 190 million people and male factor is one of the important reason (50% of the total cases) couple infertility. Semen analysis is considered as the cornerstone for laboratory evaluation of male infertility. Manual semen analysis can assess the macroscopic (pH, volume and appearance) and microscopic (sperm concentration, % total […]
A microfluidic sperm-sorting device reduces the proportion of sperm with double-stranded DNA fragmentation
La fragmentación del ADN espermático se puede producir en una (ssSDF) o en ambas (dsSDF) cadenas del ADN, estos daños están relacionados con dificultades para lograr un embarazo de forma natural y abortos espontáneos recurrentes, respectivamente. Las técnicas que se utilizan con más frecuencia para seleccionar espermatozoides requieren de centrifugación, lo que puede aumentar el […]
Póster Congreso ESHRE20: A new oral treatment based on the ATM/ATR DNA repair pathways enhancement reduce sperm DNA damage and improve semen parameters
P-068 Study question: Can double-strand sperm DNA breaks and semen parameters be improved by oral administration of antioxidants and ATM/ATR-enhancers? Summary answer: A new treatment based on ATM/ATR-repair-pathways enhancement significantly reduced double-strand sperm DNA breaks and improved semen parameters. What is known already: Double-strand breaks (DSB) take place during male meiosis to enable DNA recombination […]
Live Morphology Imaging is a Better Approach for Observing Sperm Head Osmolality-induced Morphological Changes Compared with Diff-Quik Staining Method
Objetctive To compare the live morphology imaging technology of LensHooke® X1 PRO Semen Quality Analyzer with Diff-Quik staining in sperm head morphometric analysis. Introduction The dimensions of spermatozoa, especially head parameters, play a pivotal role for the sperm morphology assessment according to WHO 5th manual for human sperm morphology assessment.Diff-Quik is one of the staining […]
ESHRE-Evaluation of a Fully Automated Semen Quality Analyzer (LensHooke X1) for Home-based Monitoring
Introduction Home-based semen quality analyzer (HBSQA) provides private, convenient and rapid evaluation of semen samples. However, there is no information in literature on post-surgical (varicocele repair or removal of ejaculatory duct obstruction) semen quality monitoring (SQM) using HBSQA. Most HBSQA measures only one or a few parameters at a time and thus cannot replace standard […]
ASRM2020 P-498 – MICROFLUIDIC SPERM SELECTION IS AN EFFECTIVE METHOD FOR IMPROVING EMBRYO DEVELOPMENTAL COMPETENCE IN IVF WITH OLDER PATIENTS.
OBJECTIVE: Sperm DNA fragmentation can reduce the rate of embryo development and also increase the rate of miscarriage. Various methods have been developed to select and collect sperm with good motility. However, the DNA fragmentation index (DFI) of the collected sperm differs among these methods. The microfluidic sperm selection chamber (ZyMōt™; DxNow) is a selection […]
