Comparison of Sperm Selection Techniques in ICSI: Microfluidics vs. Centrifugation Gradient
The study compares two sperm selection techniques in 239 couples undergoing IVF-ICSI: the traditional centrifugation gradient method and the microfluidic technique (ZyMot ICSI). Although there were no significant differences in fertilization rates (p = 0.87), the use of microfluidics improved the blastocyst rate (p = 0.046) and clinical pregnancy (p = 0.049). The results suggest […]
Use of Microfluidics to Reduce Sperm DNA Fragmentation and Improve ICSI Outcomes
The study evaluates the use of a microfluidic device (FertileChip®, now ZyMot® ICSI) to reduce double-strand sperm DNA fragmentation, a factor associated with recurrent miscarriages and low implantation rates. In a pilot study with nine patients, the device reduced fragmentation by 46% compared to the conventional «swim-up» method. Subsequently, in 163 ICSI cycles, fertilization rates […]
Impact of the Microfluidic Device in ICSI: Improving Outcomes in Patients with High Sperm DNA Fragmentation
The study evaluates the impact of the ZyMōt™ ICSI microfluidic device on ICSI outcomes in couples with high sperm DNA fragmentation (DSB). Comparing two ICSI cycles in 28 couples—the first using conventional methods and the second using ZyMōt™ ICSI—significant improvements in clinical outcomes were observed. The biochemical pregnancy rate increased by 28.31%, the clinical pregnancy […]
ASRM2020 P-498 – MICROFLUIDIC SPERM SELECTION IS AN EFFECTIVE METHOD FOR IMPROVING EMBRYO DEVELOPMENTAL COMPETENCE IN IVF WITH OLDER PATIENTS.
OBJECTIVE: Sperm DNA fragmentation can reduce the rate of embryo development and also increase the rate of miscarriage. Various methods have been developed to select and collect sperm with good motility. However, the DNA fragmentation index (DFI) of the collected sperm differs among these methods. The microfluidic sperm selection chamber (ZyMōt™; DxNow) is a selection […]
A microfluidic sperm-sorting device reduces the proportion of sperm with double-stranded DNA fragmentation
La fragmentación del ADN espermático se puede producir en una (ssSDF) o en ambas (dsSDF) cadenas del ADN, estos daños están relacionados con dificultades para lograr un embarazo de forma natural y abortos espontáneos recurrentes, respectivamente. Las técnicas que se utilizan con más frecuencia para seleccionar espermatozoides requieren de centrifugación, lo que puede aumentar el […]
